ID   NDi001-A
AC   CVCL_YN03
SY   HL-60-iPSC c25; HL-60 iPSC c25
DR   hPSCreg; NDi001-A
DR   Wikidata; Q98127502
RX   PubMed=33370871;
CC   From: University of Notre Dame; Notre Dame; USA.
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Induced pluripotent stem cell
DT   Created: 12-03-20; Last updated: 29-06-23; Version: 8
//
RX   PubMed=33370871; DOI=10.1016/j.scr.2020.102096;
RA   Yamasaki A.E., Warshaw J.N., Kyalwazi B.L., Matsui H., Jepsen K.,
RA   Panopoulos A.D.;
RT   "An iPSC line derived from a human acute myeloid leukemia cell line
RT   (HL-60-iPSC) retains leukemic abnormalities and displays myeloid
RT   differentiation defects.";
RL   Stem Cell Res. 49:102096-102096(2020).
//