ID   HEC-1BE
AC   CVCL_YJ46
SY   HEC1BE
DR   cancercelllines; CVCL_YJ46
DR   Wikidata; Q94091657
RX   PubMed=8847459;
RX   PubMed=12893190;
RX   PubMed=15901131;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; c.4001+1G>T; ClinVar=VCV001736936; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (PubMed=15901131).
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
DI   NCIt; C7359; Endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0294 ! HEC-1-B
SX   Female
AG   71Y
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 05-10-23; Version: 8
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RX   PubMed=8847459;
RA   Okamura N., Mori Y., Endo T., Ito E., Kudo R.;
RT   "Experimental studies on the cell adhesion molecule E-cadherin and in
RT   vitro invasion of endometrial carcinoma cell lines.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 48:335-342(1996).
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RX   PubMed=12893190; DOI=10.1016/S0090-8258(03)00335-4;
RA   Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.;
RT   "Three-dimensional coculture of endometrial cancer cells and
RT   fibroblasts in human placenta derived collagen sponges and expression
RT   matrix metalloproteinases in these cells.";
RL   Gynecol. Oncol. 90:297-304(2003).
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RX   PubMed=15901131; DOI=10.1016/j.prp.2005.01.002;
RA   Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.;
RT   "Correlation between DNA alterations and p53 and p16 protein
RT   expression in cancer cell lines.";
RL   Pathol. Res. Pract. 201:109-115(2005).
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