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Cellosaurus MDA-MB-468 shWDR12-4 (CVCL_YJ27)

[Text version]
Cell line name MDA-MB-468 shWDR12-4
Accession CVCL_YJ27
Resource Identification Initiative To cite this cell line use: MDA-MB-468 shWDR12-4 (RRID:CVCL_YJ27)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: African American.
Doubling time: 24-31 hours (CelloPub=CLPUB00550).
Knockout cell: Method=shRNA knockdown; HGNC; 14098; WDR12.
Miscellaneous: Corrections of STR profile from thesis manuscript (CelloPub=CLPUB00550) from personal communication of Al-awar, Rima.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0419 (MDA-MB-468)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): CelloPub=CLPUB00550; Direct_author_submission

Markers:
AmelogeninX
CSF1PO12,13
D5S81812
D7S8208
D13S31712
D16S5399
D21S1127,28
TH017
TPOX8,9
vWA18

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Publications

CLPUB00550
Benhamron S.
Validating WDR12 as a potential drug target in triple negative breast cancer.
Thesis MSc (2019); University of Toronto; Toronto; Canada

Cross-references
Cell line databases/resources cancercelllines; CVCL_YJ27
Encyclopedic resources Wikidata; Q95987445
Entry history
Entry creation19-Dec-2019
Last entry update10-Sep-2024
Version number11