ID   E006AA ZIC2-/- E5
AC   CVCL_YI81
DR   cancercelllines; CVCL_YI81
DR   Wikidata; Q93534054
RX   CelloPub=CLPUB00549;
CC   Problematic cell line: Contaminated. Parent cell line (E006AA) has been shown to be a 786-O derivative.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:12873; ZIC2.
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4834 ! E006AA
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 19-12-24; Version: 10
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RX   CelloPub=CLPUB00549;
RA   Moore, Jennifer C.
RT   "Establishment Of CRISPR/Cas-9 aided knockout of the ZIC2 gene in the
RT   African-American prostate cancer cell line E006AA-PR.";
RL   Thesis MSc (2019); Clark Atlanta University; Atlanta; USA.
//