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Cellosaurus PK15 PERV-inactivated clone 15 (CVCL_YE75)

[Text version]
Cell line name PK15 PERV-inactivated clone 15
Synonyms PK15 clone 15; PK15-15
Accession CVCL_YE75
Resource Identification Initiative To cite this cell line use: PK15 PERV-inactivated clone 15 (RRID:CVCL_YE75)
Comments Characteristics: Using CRISPR/Cas9 all 62 copies of the PERV pol gene were inactivated (PubMed=26456528).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Breed/subspecies: Hampshire; VBO=VBO_0001146.
Hierarchy Parent: CVCL_2160 (PK-15)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=26456528; DOI=10.1126/science.aad1191
Yang L.-H., Guell M., Niu D., George H., Lesha E., Grishin D., Aach J., Shrock E., Xu W.-H., Poci J., Cortazio R., Wilkinson R.A., Fishman J.A., Church G.M.
Genome-wide inactivation of porcine endogenous retroviruses (PERVs).
Science 350:1101-1104(2015)

PubMed=31667881; DOI=10.1111/xen.12563
Godehardt A.W., Fischer N., Rauch P., Gulich B., Boller K., Church G.M., Tonjes R.R.
Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15.
Xenotransplantation 27:e12563.1-e12563.12(2020)

Cross-references
Encyclopedic resources Wikidata; Q98128600
Entry history
Entry creation19-Dec-2019
Last entry update10-Sep-2024
Version number5