Cellosaurus cell line CHO-K1 Ed-A1 (CVCL

Cellosaurus CHO-K1 Ed-A1 (CVCL_YD18)

Cross-references
Cell line name	CHO-K1 Ed-A1
Synonyms	Ed-A1
Accession	CVCL_YD18
Resource Identification Initiative	To cite this cell line use: CHO-K1 Ed-A1 (RRID:CVCL_YD18)
Comments	Characteristics: Has reduced Na+-dependent glutamate transport activity. Have an increased permeability to small neutral molecules. Characteristics: Selection is effected by tritium suicide selection. Mutagenized cells are bathed in tritiated D-aspartate and stored so as to allow time for cells that had taken up the D-aspartate to be killed by radiation damage. Selected for resistance to: NCIt; C165595; Tritium beta radiation. Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE). Derived from site: In situ; Ovary; UBERON=UBERON_0000992. Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy	Parent: CVCL_0214 (CHO-K1)
Sex of cell	Female
Age at sampling	Adult
Category	Transformed cell line
Publications	PubMed=8101392; DOI=10.1007/BF01233071 Ash J.F., Igo R.P. Jr., Morgan M., Grey A. Selection of Chinese hamster ovary cells (CHO-K1) with reduced glutamate and aspartate uptake. Somat. Cell Mol. Genet. 19:231-243(1993) PubMed=8782489; DOI=10.1007/BF02369900 Igo R.P. Jr., Ash J.F. New mutations and phenotypes associated with glutamate and aspartate transport in Chinese hamster ovary (CHO-K1) cells. Somat. Cell Mol. Genet. 22:87-103(1996) PubMed=9075644; DOI=10.1007/s002329900195 Tong X., Ash J.F., Caldwell K.D. Rapid swelling of a CHO-K1 aspartate/glutamate transport mutant in hypo-osmotic medium. J. Membr. Biol. 156:131-139(1997)
Encyclopedic resources	Wikidata; Q93451727
Entry history
Entry creation	19-Dec-2019
Last entry update	19-Dec-2024
Version number	7