Cellosaurus cell line MDA-MB-231T (CVCL

Cellosaurus MDA-MB-231T (CVCL_YA89)

Cross-references
Cell line name	MDA-MB-231T
Synonyms	MB231T
Accession	CVCL_YA89
Resource Identification Initiative	To cite this cell line use: MDA-MB-231T (RRID:CVCL_YA89)
Comments	Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Characteristics: Has metastatic potential. Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease	Breast adenocarcinoma (NCIt: C5214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0062 (MDA-MB-231)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Publications	PubMed=15870434; DOI=10.1093/jnci/dji111 Palmieri D., Halverson D.O., Ouatas T., Horak C.E., Salerno M., Johnson J., Figg W.D., Hollingshead M.G., Hursting S.D., Berrigan D., Steinberg S.M., Merino M.J., Steeg P.S. Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer. J. Natl. Cancer Inst. 97:632-642(2005)
Cell line databases/resources	cancercelllines; CVCL_YA89
Encyclopedic resources	Wikidata; Q95987395
Gene expression databases	GEO; GSM1178375 GEO; GSM1178376
Entry history
Entry creation	19-Dec-2019
Last entry update	05-Oct-2023
Version number	7