Cellosaurus cell line LA11 (CVCL

Cross-references
Cell line name	LA11
Synonyms	PARK8-LA11; HPS0103
Accession	CVCL_Y951
Resource Identification Initiative	To cite this cell line use: LA11 (RRID:CVCL_Y951)
Comments	Population: Japanese. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:18618; LRRK2; Simple; p.Ile2020Thr (c.6059C>T); ClinVar=VCV000001941; Zygosity=Heterozygous (PubMed=26056228).
Disease	Parkinson disease 8, autosomal dominant (NCIt: C198605) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_T963 ! LA3 CVCL_Y949 ! LA5 CVCL_Y950 ! LA8
Sex of cell	Female
Age at sampling	66Y
Category	Induced pluripotent stem cell
Publications	PubMed=26056228; DOI=10.1093/hmg/ddv212 Ohta E., Nihira T., Uchino A., Imaizumi Y., Okada Y., Akamatsu W., Takahashi K., Hayakawa H., Nagai M., Ohyama M., Ryo M., Ogino M., Murayama S., Takashima A., Nishiyama K., Mizuno Y., Mochizuki H., Obata F., Okano H. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway. Hum. Mol. Genet. 24:4879-4900(2015)
Cell line databases/resources	SKIP; SKIP000992
Encyclopedic resources	Wikidata; Q54901885
Entry history
Entry creation	10-Apr-2015
Last entry update	19-Dec-2024
Version number	9