Cellosaurus cell line Rh28/L-PAM (CVCL

Cellosaurus Rh28/L-PAM (CVCL_Y584)

Cross-references
Cell line name	Rh28/L-PAM
Synonyms	Rh28 L-PAM; Rh28/LPAM; RH28/LPAM; Rh 28/LPAM; Rh28 PX11/LPAM; Rh-28 PX11/LPAM
Accession	CVCL_Y584
Resource Identification Initiative	To cite this cell line use: Rh28/L-PAM (RRID:CVCL_Y584)
Comments	Selected for resistance to: ChEBI; CHEBI:28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran). Derived from site: Metastatic; Axillary lymph node; UBERON=UBERON_0001097.
Sequence variations	Gene fusion; HGNC; 3819; FOXO1 + HGNC; 8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR (from parent cell line). Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Heterozygous (from parent cell line).
Disease	Alveolar rhabdomyosarcoma (NCIt: C3749) Alveolar rhabdomyosarcoma (ORDO: Orphanet_99756)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_8752 (Rh28)
Sex of cell	Male
Age at sampling	17Y
Category	Cancer cell line
Publications	PubMed=2890432 Horton J.K., Houghton P.J., Houghton J.A. Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard. Cancer Res. 47:6288-6293(1987) PubMed=23882450; DOI=10.3389/fonc.2013.00183; PMCID=PMC3713458 Hinson A.R.P., Jones R., Crose L.E.S., Belyea B.C., Barr F.G., Linardic C.M. Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls. Front. Oncol. 3:183.1-183.12(2013) PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476 Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J. Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression. Mol. Cancer Ther. 14:2452-2462(2015)
Encyclopedic resources	Wikidata; Q54950337
Gene expression databases	GEO; GSM1676360 GEO; GSM1701690
Entry history
Entry creation	10-Apr-2015
Last entry update	29-Jun-2023
Version number	12