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Cellosaurus Rh28/L-PAM (CVCL_Y584)

[Text version]
Cell line name Rh28/L-PAM
Synonyms Rh28 L-PAM; Rh28/LPAM; RH28/LPAM; Rh 28/LPAM; Rh28 PX11/LPAM; Rh-28 PX11/LPAM
Accession CVCL_Y584
Resource Identification Initiative To cite this cell line use: Rh28/L-PAM (RRID:CVCL_Y584)
Comments Selected for resistance to: ChEBI; CHEBI:28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran).
Derived from site: Metastatic; Axillary lymph node; UBERON=UBERON_0001097.
Sequence variations
  • Gene fusion; HGNC; 3819; FOXO1 + HGNC; 8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Heterozygous (from parent cell line).
Disease Alveolar rhabdomyosarcoma (NCIt: C3749)
Alveolar rhabdomyosarcoma (ORDO: Orphanet_99756)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8752 (Rh28)
Sex of cell Male
Age at sampling 17Y
Category Cancer cell line
Publications

PubMed=2890432
Horton J.K., Houghton P.J., Houghton J.A.
Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard.
Cancer Res. 47:6288-6293(1987)

PubMed=23882450; DOI=10.3389/fonc.2013.00183
Hinson A.R.P., Jones R., Crose L.E.S., Belyea B.C., Barr F.G., Linardic C.M.
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Front. Oncol. 3:183.1-183.12(2013)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

Cross-references
Encyclopedic resources Wikidata; Q54950337
Gene expression databases GEO; GSM1676360
GEO; GSM1701690
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number12