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Cellosaurus HG-3 (CVCL_Y547)

[Text version]
Cell line name HG-3
Synonyms HG3
Accession CVCL_Y547
Resource Identification Initiative To cite this cell line use: HG-3 (RRID:CVCL_Y547)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Characteristics: Genetically heterogeneous, consists of 3 subclones (PubMed=27566572).
Doubling time: ~50-70 hours (DSMZ=ACC-765).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: DSMZCellDive=ACC-765
Class I
HLA-AA*11:01:01,31:01:02
HLA-BB*07:02:01,15:01:01
HLA-CC*03:03:01,07:02:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:02:01,04:01:01
HLA-DQDQA1*01:02:01,01:04:01
DQB1*05:03:01,06:02:01
HLA-DRDRA*01:01:01,01:02:03
DRB1*14:54:01,15:01:01
Disease Chronic lymphocytic leukemia (NCIt: C3163)
B-cell chronic lymphocytic leukemia (ORDO: Orphanet_67038)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Transformed cell line
STR profile Source(s): DepMap; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,14
D2S133817
D3S135817,18
D5S81811
D7S8208,13
D8S117911,15
D13S31711,13
D16S5399,12
D18S5114,16
D19S43315,16
D21S1129,30
FGA23,24
Penta D9,10
Penta E11,12
TH017,9.3
TPOX8,12
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=22720208; DOI=10.4161/onci.1.1.18400
Rosen A., Bergh A.-C., Gogolak P., Evaldsson C., Myhrinder A.L., Hellqvist E., Rasul A., Bjorkholm M., Jansson M., Mansouri L., Liu A.-Q., Teh B.T., Rosenquist R., Klein E.
Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection.
OncoImmunology 1:18-27(2012)

PubMed=23297799; DOI=10.3109/10428194.2013.764418
Myhrinder A.L., Hellqvist E., Bergh A.-C., Jansson M., Nilsson K., Hultman P., Jonasson J., Buhl A.M., Pedersen L.B., Jurlander J., Klein E., Weit N., Herling M., Rosenquist R., Rosen A.
Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.
Leuk. Lymphoma 54:1769-1779(2013)

PubMed=27566572; DOI=10.18632/oncotarget.11524
Quentmeier H., Pommerenke C., Ammerpohl O., Geffers R., Hauer V., MacLeod R.A.F., Nagel S., Romani J., Rosati E., Rosen A., Uphoff C.C., Zaborski M., Drexler H.G.
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Oncotarget 7:63456-63465(2016)

PubMed=28489572; DOI=10.18632/oncotarget.17246
Russo M., Milito A., Spagnuolo C., Carbone V., Rosen A., Minasi P., Lauria F., Russo G.L.
CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia.
Oncotarget 8:42571-42587(2017)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-765
Cell line databases/resources Cell_Model_Passport; SIDM01817
DepMap; ACH-001520
DSMZCellDive; ACC-765
Encyclopedic resources Wikidata; Q54883310
Gene expression databases ArrayExpress; E-MTAB-4527
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Entry history
Entry creation07-Nov-2014
Last entry update29-Jun-2023
Version number14