ID   41M:RD1694
AC   CVCL_Y427
DR   cancercelllines; CVCL_Y427
DR   Wikidata; Q54602998
RX   PubMed=7537518;
CC   Problematic cell line: Contaminated. Parent cell line (41M) has been shown to be a OAW28 derivative.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4993 ! 41M
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 05-10-23; Version: 14
RX   PubMed=7537518; DOI=10.1038/bjc.1995.178;
RA   Jackman A.L., Kelland L.R., Kimbell R., Brown M., Gibson W.,
RA   Aherne G.W., Hardcastle A., Boyle F.T.;
RT   "Mechanisms of acquired resistance to the quinazoline thymidylate
RT   synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell
RT   lines.";
RL   Br. J. Cancer 71:914-924(1995).