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Cellosaurus CH1:RD1694 (CVCL_Y426)

[Text version]
Cell line name CH1:RD1694
Accession CVCL_Y426
Resource Identification Initiative To cite this cell line use: CH1:RD1694 (RRID:CVCL_Y426)
Comments Problematic cell line: Contaminated. Parent cell line (CH1) has been shown to be a PA-1 derivative.
Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4992 (CH1 [Human ovarian carcinoma])
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line

PubMed=7537518; DOI=10.1038/bjc.1995.178
Jackman A.L., Kelland L.R., Kimbell R., Brown M., Gibson W., Aherne G.W., Hardcastle A., Boyle F.T.
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Br. J. Cancer 71:914-924(1995)

Cell line databases/resources cancercelllines; CVCL_Y426
Encyclopedic resources Wikidata; Q54811612
Entry history
Entry creation07-Nov-2014
Last entry update05-Oct-2023
Version number15