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Cellosaurus WIL2:RD1694 (CVCL_Y425)

[Text version]
Cell line name WIL2:RD1694
Accession CVCL_Y425
Resource Identification Initiative To cite this cell line use: WIL2:RD1694 (RRID:CVCL_Y425)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=7537518; DOI=10.1038/bjc.1995.178; PMCID=PMC2033796
Jackman A.L., Kelland L.R., Kimbell R., Brown M., Gibson W., Aherne G.W., Hardcastle A., Boyle F.T.
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Br. J. Cancer 71:914-924(1995)

Cross-references
Encyclopedic resources Wikidata; Q54994069
Entry history
Entry creation07-Nov-2014
Last entry update29-Jun-2023
Version number11