Cell line name |
T24/DDP5 |
Accession |
CVCL_Y182 |
Resource Identification Initiative |
To cite this cell line use: T24/DDP5 (RRID:CVCL_Y182) |
Comments |
Population: Caucasian; Swedish. Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP). Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255. |
Sequence variations |
- Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
|
Disease |
Bladder carcinoma (NCIt: C4912) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0554 (T24) |
Sex of cell |
Female |
Age at sampling |
82Y |
Category |
Cancer cell line |
Publications | PubMed=8205547 Kotoh S., Naito S., Yokomizo A., Kumazawa J., Asakuno K., Kohno K., Kuwano M. Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells. Cancer Res. 54:3248-3252(1994) PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2 Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J. Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 64:1403-1410(2004) PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350 Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D. Systematic review: characteristics and preclinical uses of bladder cancer cell lines. Bladder Cancer 4:169-183(2018) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_Y182
CGH-DB; 9113-4
|
Encyclopedic resources |
Wikidata; Q54971458
|
Entry history |
Entry creation | 07-Nov-2014 |
Last entry update | 19-Dec-2024 |
Version number | 14 |
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