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Cellosaurus U937/UK110 (CVCL_Y174)

[Text version]
Cell line name U937/UK110
Synonyms UK110
Accession CVCL_Y174
Resource Identification Initiative To cite this cell line use: U937/UK110 (RRID:CVCL_Y174)
Comments Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=8845304
Kohji Noguchi, Mikihiko Naito, Shiro Kataoka, Shin Yonehara, Takashi Tsuruo;
A recessive mutant of the U937 cell line acquired resistance to anti-Fas and anti-p55 tumor necrosis factor receptor antibody-induced apoptosis.
Cell Growth Differ. 6:1271-1277(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y174
Encyclopedic resources Wikidata; Q54973785
Entry history
Entry creation07-Nov-2014
Last entry update19-Dec-2024
Version number14