ID   HAP1
AC   CVCL_Y019
SY   HAP-1
DR   EFO; EFO_0007598
DR   4DN; 4DNSRCVNIBZG
DR   4DN; 4DNSRNIAESOK
DR   ArrayExpress; E-MTAB-7061
DR   BioGRID_ORCS_Cell_line; 1143
DR   cancercelllines; CVCL_Y019
DR   ChEMBL-Cells; CHEMBL4630769
DR   ChEMBL-Targets; CHEMBL4630777
DR   DepMap; ACH-002475
DR   ENCODE; ENCBS217AEF
DR   ENCODE; ENCBS912MMS
DR   Horizon_Discovery; C631
DR   PRIDE; PXD006614
DR   PRIDE; PXD006856
DR   PRIDE; PXD010335
DR   PubChem_Cell_line; CVCL_Y019
DR   Wikidata; Q18347803
RX   PubMed=21866103;
RX   PubMed=24644259;
RX   PubMed=25373145;
RX   PubMed=29474001;
RX   PubMed=31659326;
RX   PubMed=33184093;
WW   https://en.wikipedia.org/wiki/HAP1_cells
CC   Group: Haploid karyotype cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Karyotypic information: Has lost the second copy of chromosome 8 of parent cell line KBM-7. Retains a second copy of a fragment of chromosome 15 fused to chromosome 19.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Omics: Deep proteome analysis.
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): Technion Genomics Center BCF
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D10S1248: 15
ST   D12S391: 18
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 18
ST   D19S433: 15
ST   D1S1656: 17.3
ST   D21S11: 30
ST   D22S1045: 16
ST   D2S1338: 25
ST   D2S441: 14
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 9
ST   D8S1179: 8,14
ST   FGA: 21
ST   Penta D: 9
ST   Penta E: 10
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A426 ! KBM-7
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 02-05-24; Version: 25
//
RX   PubMed=21866103; DOI=10.1038/nature10348;
RA   Carette J.E., Raaben M., Wong A.C., Herbert A.S., Obernosterer G.,
RA   Mulherkar N., Kuehne A.I., Kranzusch P.J., Griffin A.M., Ruthel G.,
RA   Dal Cin P.S., Dye J.M., Whelan S.P.J., Chandran K., Brummelkamp T.R.;
RT   "Ebola virus entry requires the cholesterol transporter Niemann-Pick
RT   C1.";
RL   Nature 477:340-343(2011).
//
RX   PubMed=24644259; DOI=10.1242/dev.102202;
RA   Wutz A.;
RT   "Haploid animal cells.";
RL   Development 141:1423-1426(2014).
//
RX   PubMed=25373145; DOI=10.1101/gr.177220.114;
RA   Essletzbichler P., Konopka T., Santoro F., Chen D., Gapp B.V.,
RA   Kralovics R., Brummelkamp T.R., Nijman S.M.B., Burckstummer T.;
RT   "Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid
RT   human cell line.";
RL   Genome Res. 24:2059-2065(2014).
//
RX   PubMed=29474001; DOI=10.1002/pmic.201700386;
RA   Lee S.-E., Song J., Bosl K., Muller A.C., Vitko D., Bennett K.L.,
RA   Superti-Furga G., Pandey A., Kandasamy R.K., Kim M.S.;
RT   "Proteogenomic analysis to identify missing proteins from haploid cell
RT   lines.";
RL   Proteomics 18:1700386.1-1700386.9(2018).
//
RX   PubMed=31659326; DOI=10.1038/s41592-019-0614-5;
RA   Smits A.H., Ziebell F., Joberty G., Zinn N., Mueller W.F.,
RA   Clauder-Munster S., Eberhard D., Falth Savitski M., Grandi P.,
RA   Jakob P., Michon A.-M., Sun H., Tessmer K., Burckstummer T.,
RA   Bantscheff M., Steinmetz L.M., Drewes G., Huber W.;
RT   "Biological plasticity rescues target activity in CRISPR knock outs.";
RL   Nat. Methods 16:1087-1093(2019).
//
RX   PubMed=33184093; DOI=10.1242/bio.057174;
RA   Beigl T.B., Kjosas I., Seljeseth E., Glomnes N., Aksnes H.;
RT   "Efficient and crucial quality control of HAP1 cell ploidy status.";
RL   Biol. Open 9:bio057174.1-bio057174.8(2020).
//