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Cellosaurus AsPC1-R (CVCL_XX79)

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Cell line name AsPC1-R
Accession CVCL_XX79
Resource Identification Initiative To cite this cell line use: AsPC1-R (RRID:CVCL_XX79)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene deletion; HGNC; HGNC:6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); ClinVar=VCV001069265; Zygosity=Heterozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0152 (AsPC-1)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=27910856; DOI=10.1038/cgt.2016.71; PMCID=PMC5159445
Roman Mezencev, Lilya V. Matyunina, G.T. Wagner, John F. McDonald;
Acquired resistance of pancreatic cancer cells to cisplatin is multifactorial with cell context-dependent involvement of resistance genes.
Cancer Gene Ther. 23:446-453(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XX79
Encyclopedic resources Wikidata; Q93326176
Gene expression databases GEO; GSM1906988
GEO; GSM1906989
GEO; GSM1906990
Entry history
Entry creation19-Dec-2019
Last entry update10-Apr-2025
Version number10