ID   VU-SCC-1604
AC   CVCL_XX20
SY   VU1604
DR   Wikidata; Q98134590
RX   PubMed=26122845;
RX   PubMed=31541927;
RX   PubMed=36912284;
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg21Lys (c.62G>A); ClinVar=VCV000371974; Zygosity=Homozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Asn (c.250G>A) (p.Arg98Gln, c.293G>A); ClinVar=VCV000229806; Zygosity=Homozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Gln1455Ter (c.4363C>T); Zygosity=Homozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Pro1131Leu (c.3392C>T); ClinVar=VCV000134672; Zygosity=Homozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (PubMed=31541927).
CC   Omics: Genome sequenced (low read coverage).
ST   Source(s): PubMed=36912284
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,11
ST   D16S539: 11
ST   D5S818: 11
ST   D7S820: 8,11
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17,20
DI   NCIt; C164677; Fanconi anemia, complementation group L
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_84; Fanconi anemia
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 19-12-24; Version: 9
//
RX   PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528;
RA   Stoepker C., Ameziane N., van der Lelij P., Kooi I.E., Oostra A.B.,
RA   Rooimans M.A., van Mil S.E., Brink A., Dietrich R., Balk J.A.,
RA   Ylstra B., Joenje H., Feller S.M., Brakenhoff R.H.;
RT   "Defects in the Fanconi anemia pathway and chromatid cohesion in head
RT   and neck cancer.";
RL   Cancer Res. 75:3543-3553(2015).
//
RX   PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097;
RA   van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I.,
RA   Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.;
RT   "Characterization of a head and neck cancer-derived cell line panel
RT   confirms the distinct TP53-proficient copy number-silent subclass.";
RL   Oral Oncol. 98:53-61(2019).
//
RX   PubMed=36912284; DOI=10.1002/ijc.34506;
RA   Nguyen H.T., Tang W.-L., Webster A.L.H., Whiteaker J.R., Chandler C.M.,
RA   Errazquin Ciudad R., Roohollahi K., Fritzke M., Hoskins E.E., Jonlin E.C.,
RA   Wakefield L., Sullivan L.B., Chen E.Y., Dorsman J.C., Brakenhoff R.H.,
RA   Paulovich A.G., Grompe M., Garcia-Escudero R., Wells S.I.,
RA   Smogorzewska A., Monnat R.J. Jr.;
RT   "Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic
RT   and translational science resource.";
RL   Int. J. Cancer 153:183-196(2023).
//