ID   HaCaT RT3
AC   CVCL_XK15
SY   A-5RT3; RT3
DR   PRIDE; PXD013113
DR   Wikidata; Q93937698
RX   PubMed=11583982;
RX   PubMed=20097197;
CC   Population: Caucasian.
CC   Characteristics: Metastatic.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5173; HRAS.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XK16 ! HaCaT A-5
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 19-12-19; Last updated: 27-11-25; Version: 10
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RX   PubMed=11583982; DOI=10.1016/S0002-9440(10)62541-2; PMCID=PMC1850484;
RA   Mueller, Margareta M.
RA   Peter, Wolfgang
RA   Mappes, Marion
RA   Huelsen, Andrea
RA   Steinbauer, Heinrich
RA   Boukamp, Petra
RA   Vaccariello, Michael Anthony
RA   Garlick, Jonathan A.
RA   Fusenig, Norbert E.
RT   "Tumor progression of skin carcinoma cells in vivo promoted by clonal
RT   selection, mutagenesis, and autocrine growth regulation by granulocyte
RT   colony-stimulating factor and granulocyte-macrophage
RT   colony-stimulating factor.";
RL   Am. J. Pathol. 159:1567-1579(2001).
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RX   PubMed=20097197; DOI=10.1016/j.yexcr.2010.01.020;
RA   Rasanen, Kati
RA   Vaheri, Antti
RT   "Proliferation and motility of HaCaT keratinocyte derivatives is
RT   enhanced by fibroblast nemosis.";
RL   Exp. Cell Res. 316:1739-1747(2010).
//