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Cellosaurus HepaRG-CAR (CVCL_XI49)

[Text version]
Cell line name HepaRG-CAR
Accession CVCL_XI49
Resource Identification Initiative To cite this cell line use: HepaRG-CAR (RRID:CVCL_XI49)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-3291.
Characteristics: Compared to the parent cell line, has improved liver functionality. Drug metabolism is highly improved. Culturing can be performed in serum-free conditions both in the presence or absence of DMSO.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7969; NR1I3.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatitis C infection (NCIt: C3098)
Hepatocellular carcinoma (NCIt: C3099)
Hepatocellular carcinoma (ORDO: Orphanet_88673)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9720 (HepaRG)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=27780834; DOI=10.1124/dmd.116.072603
van der Mark V.A., de Waart D.R., Shevchenko V., Oude Elferink R.P.J., Chamuleau R.A.F.M., Hoekstra R.
Stable overexpression of the constitutive androstane receptor reduces the requirement for culture with dimethyl sulfoxide for high drug metabolism in HepaRG cells.
Drug Metab. Dispos. 45:56-67(2017)

Patent=US20190256822
van der Mark V.A.
Hepatic cell line resistant to dimethyl sulfoxide, cell culture and uses thereof.
Patent number US20190256822, 22-Aug-2019

PubMed=32130581; DOI=10.1007/s10616-020-00384-w; PMCID=PMC7225227
Adam A.A.A., Jongejan A., Moerland P.D., van der Mark V.A., Oude Elferink R.P.J., Chamuleau R.A.F.M., Hoekstra R.
Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR.
Cytotechnology 72:377-395(2020)

Cross-references
Encyclopedic resources Wikidata; Q94103091
Entry history
Entry creation19-Dec-2019
Last entry update19-Dec-2024
Version number11