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Cellosaurus THP-1 TLR9 mCherry (CVCL_XI47)

[Text version]
Cell line name THP-1 TLR9 mCherry
Accession CVCL_XI47
Resource Identification Initiative To cite this cell line use: THP-1 TLR9 mCherry (RRID:CVCL_XI47)
Comments Population: Japanese.
Characteristics: Transfected with a Tet-on system so as to induce the expression of a TLR9-mCherry fusion protein with the addition of doxycycline to the culture medium.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 15633; TLR9.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

CLPUB00539
Cemalovic E.
TLR9 trafficking and signaling.
Thesis MSc (2019); Norwegian University of Science and Technology; Trondheim; Norway

CLPUB00540
Wang C.
Characterization of a model cell line to study Toll-like receptor 9 signaling and trafficking.
Thesis MSc (2019); Norwegian University of Science and Technology; Trondheim; Norway

Cross-references
Cell line databases/resources cancercelllines; CVCL_XI47
Encyclopedic resources Wikidata; Q98133245
Entry history
Entry creation19-Dec-2019
Last entry update10-Sep-2024
Version number10