ID   SAM-6
AC   CVCL_XI23
SY   SAM-6.10
DR   Wikidata; Q98129319
RX   Patent=US9273125;
RX   Patent=WO2009104100A2;
RX   PubMed=15173000;
RX   PubMed=17237291;
RX   PubMed=18268478;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2903.
CC   Monoclonal antibody isotype: IgM.
CC   Monoclonal antibody target: UniProtKB; P11021; Human HSPA5/GRP78 (isoform SAM-6).
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_9V19 ! HAB-1
CA   Hybridoma
DT   Created: 19-12-19; Last updated: 21-03-23; Version: 4
//
RX   Patent=US9273125;
RA   Vollmers H.P.;
RT   "Human monoclonal antibody having fat-reducing effect.";
RL   Patent number US9273125, 01-Mar-2016.
//
RX   Patent=WO2009104100A2;
RA   Vollmers H.P., Hensel F., Power B.E., Ilag L.L., Kelter A.-R.,
RA   Schoenen F., Muller-Hermelink H.-K., Thalheimer A., Udabage L.,
RA   Brandlein S.U.;
RT   "Antibody combinations, and methods of making and using same.";
RL   Patent number WO2009104100A2, 27-Aug-2009.
//
RX   PubMed=15173000; DOI=10.1158/0008-5472.CAN-03-3149;
RA   Pohle T., Brandlein S.U., Ruoff N., Muller-Hermelink H.-K.,
RA   Vollmers H.P.;
RT   "Lipoptosis: tumor-specific cell death by antibody-induced
RT   intracellular lipid accumulation.";
RL   Cancer Res. 64:3900-3906(2004).
//
RX   PubMed=17237291; DOI=10.1158/1535-7163.MCT-06-0399;
RA   Brandlein S.U., Rauschert N., Rasche L., Dreykluft A., Hensel F.,
RA   Conzelmann E., Muller-Hermelink H.-K., Vollmers H.P.;
RT   "The human IgM antibody SAM-6 induces tumor-specific apoptosis with
RT   oxidized low-density lipoprotein.";
RL   Mol. Cancer Ther. 6:326-333(2007).
//
RX   PubMed=18268478; DOI=10.1038/labinvest.2008.2;
RA   Rauschert N., Brandlein S.U., Holzinger E., Hensel F.,
RA   Muller-Hermelink H.-K., Vollmers H.P.;
RT   "A new tumor-specific variant of GRP78 as target for antibody-based
RT   therapy.";
RL   Lab. Invest. 88:375-386(2008).
//