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Cellosaurus JPM50.6 (CVCL_XF36)

[Text version]
Cell line name JPM50.6
Synonyms JPM 50.6; Jurkat PMA-deficient Mutant clone 50.6
Accession CVCL_XF36
Resource Identification Initiative To cite this cell line use: JPM50.6 (RRID:CVCL_XF36)
Comments Population: Caucasian.
Characteristics: CARMA1-deficient mutant.
Characteristics: The eGFP reporter gene is under the control of four tandem copies of the NF-kappaB response element.
Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XF35 (JGFP1)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=12154356; DOI=10.1038/ni824
Wang D.-H., You Y., Case S.M., McAllister-Lucas L.M., Wang L., DiStefano P.S., Nunez G., Bertin J., Lin X.
A requirement for CARMA1 in TCR-induced NF-kappa B activation.
Nat. Immunol. 3:830-835(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XF36
Encyclopedic resources Wikidata; Q94331692
Experimental variables resources EFO; EFO_0022541
Entry history
Entry creation06-Sep-2019
Last entry update19-Dec-2024
Version number12