ID   A375sci
AC   CVCL_XE59
DR   cancercelllines; CVCL_XE59
DR   CCRID; 4201PAT-CCTCC00306
DR   Wikidata; Q93311762
RX   Patent=CN102067828B;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C200954.
CC   Population: Caucasian.
CC   Characteristics: Highly metastatic.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 05-10-23; Version: 10
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RX   Patent=CN102067828B;
RA   Yao M., Wang X.-M., Yan M.-X., Kong H.-W., Liu L., Sa B.-Q., Li J.;
RT   "Highly metastatic model of human melanoma, cell subline, creation
RT   methods, and dynamic detection of metastasis.";
RL   Patent number CN102067828B, 10-Jul-2013.
//