ID   HEC-1-B-Cas9-584
AC   CVCL_XC88
DR   cancercelllines; CVCL_XC88
DR   CCRID; 1101HUM-PUMC000584
DR   Wikidata; Q94091546
CC   Population: Japanese.
CC   Characteristics: Transduced with a Cas9-Flag-Neo construct.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; c.4001+1G>T; ClinVar=VCV001736936; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
ST   Source(s): CCRID=1101HUM-PUMC000584
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D12S391: 18,19
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 16,20
ST   D19S433: 13
ST   D21S11: 30,31
ST   D2S1338: 18,19
ST   D3S1358: 15
ST   D5S818: 11,13
ST   D6S1043: 12,18
ST   D7S820: 9,11
ST   D8S1179: 13,14
ST   FGA: 21
ST   Penta E: 11
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C7359; Endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0294 ! HEC-1-B
SX   Female
AG   71Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 10-09-24; Version: 11
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