ID   HCC1954-LeptoM
AC   CVCL_XA23
SY   HCC1954 LeptoM
DR   cancercelllines; CVCL_XA23
DR   GEO; GSM2194092
DR   GEO; GSM2194093
DR   GEO; GSM2194094
DR   Wikidata; Q93982608
RX   PubMed=28283064;
WW   https://apps.cnio.es/app/BrainMetastasis/CellLines
CC   Part of: Brain metastasis cell lines panel.
CC   Population: East Indian.
CC   Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases.
CC   Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL) and with PuroR/pac.
CC   Sequence variation: Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
DI   NCIt; C4017; Breast ductal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VR24 ! HCC1954-TGL
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 05-10-23; Version: 10
//
RX   PubMed=28283064; DOI=10.1016/j.cell.2017.02.025;
RA   Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E.,
RA   Massague J.;
RT   "Complement component 3 adapts the cerebrospinal fluid for
RT   leptomeningeal metastasis.";
RL   Cell 168:1101-1113.e13(2017).
//