ID   MEL-1 INSGFP/w NEUROD1(-/-)
AC   CVCL_XA17
DR   Wikidata; Q95988516
RX   PubMed=31519700;
CC   Characteristics: Using homologous recombination an EGFP reporter gene was introduced in the INS locus (PubMed=31519700).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:7762; NEUROD1.
CC   Genetic integration: Method=Homologous recombination; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XA16 ! MEL-1 INSGFP/w
SX   Male
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-09-19; Last updated: 19-12-24; Version: 6
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RX   PubMed=31519700; DOI=10.2337/db19-0117; PMCID=PMC6868472;
RA   Romer A.I., Singer R.A., Sui L., Egli D.M., Sussel L.G.;
RT   "Murine perinatal beta-cell proliferation and the differentiation of
RT   human stem cell-derived insulin-expressing cells require NEUROD1.";
RL   Diabetes 68:2259-2271(2019).
//