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Cellosaurus JA2/R7Hyg (CVCL_X704)

[Text version]
Cell line name JA2/R7Hyg
Accession CVCL_X704
Resource Identification Initiative To cite this cell line use: JA2/R7Hyg (RRID:CVCL_X704)
Comments Population: Caucasian.
Characteristics: Transfected with plasmid R7hyg containing a human immunodeficiency virus 1 (HIV-1) isolate HXB2 proviral clone containing HygR in place of the HIV-1 nef gene (PubMed=7523570).
Genetic integration: Method=Transfection; Gene=HGNC; 4931; HLA-A (Note=Allele A*02).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X703 (Jurkat-A2)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=7523570; DOI=10.1084/jem.180.4.1283; PMCID=PMC2191672
Tsomides T.J., Aldovini A., Johnson R.P., Walker B.D., Young R.A., Eisen H.N.
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
J. Exp. Med. 180:1283-1293(1994)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-2682
Cell line databases/resources cancercelllines; CVCL_X704
Encyclopedic resources Wikidata; Q54898503
Entry history
Entry creation05-Sep-2014
Last entry update10-Sep-2024
Version number17