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Cellosaurus CEM.NKR-CCR5-Luc (CVCL_X624)

[Text version]
Cell line name CEM.NKR-CCR5-Luc
Synonyms CEM-NKR-CCR5-Luc; CEM-NKr-CCR5-Luc; CEM.NKR CCR5+Luc+; CEM-R5
Accession CVCL_X624
Resource Identification Initiative To cite this cell line use: CEM.NKR-CCR5-Luc (RRID:CVCL_X624)
Comments Population: Caucasian.
Characteristics: Resistant to NK cell-mediated cell lysis (from parent cell line).
Characteristics: The luciferase reporter gene is under the transcriptional control of the HIV-2 LTR.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X623 (CEM.NKR-CCR5)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=11162843; DOI=10.1006/viro.2000.0780
Spenlehauer C., Gordon C.A., Trkola A., Moore J.P.
A luciferase-reporter gene-expressing T-cell line facilitates neutralization and drug-sensitivity assays that use either R5 or X4 strains of human immunodeficiency virus type 1.
Virology 280:292-300(2001)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-5198
Cell line databases/resources cancercelllines; CVCL_X624
Encyclopedic resources Wikidata; Q54809265
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number22