ID   THP1-XBlue-defMyD
AC   CVCL_X586
DR   cancercelllines; CVCL_X586
DR   Wikidata; Q54972377
RX   PubMed=25130606;
WW   https://www.invivogen.com/thp1-xblue-defmyd-cell
CC   Population: Japanese.
CC   Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a NF-KappaB/AP-1 promoter.
CC   Sequence variation: Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 439; ALPP.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X582 ! THP1-Xblue
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 10-09-24; Version: 17
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RX   PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002;
RA   Chanput W., Mes J.J., Wichers H.J.;
RT   "THP-1 cell line: an in vitro cell model for immune modulation
RT   approach.";
RL   Int. Immunopharmacol. 23:37-45(2014).
//