ID   RCC52
AC   CVCL_X534
DR   Wikidata; Q54949468
RX   PubMed=18704411;
RX   PubMed=24222125;
CC   Population: Chinese.
CC   Doubling time: 23.4 hours (PubMed=24222125).
CC   HLA typing: A*02,11; B*46,60(40); C*w01,w07 (PubMed=18704411).
CC   Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Ala6Profs*1 (c.16delG); Zygosity=Heterozygous (PubMed=18704411).
CC   Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous; Note=Total loss of HLA class 1 expression (PubMed=18704411).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C27893; Sarcomatoid renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 19-12-24; Version: 13
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RX   PubMed=18704411; DOI=10.1007/s00262-008-0565-7; PMCID=PMC2793116;
RA   Hsieh C.-H., Hsu Y.-J., Chang C.-C., Liu H.-C., Chuang K.-L.,
RA   Chuang C.-K., Pang S.-T., Hasumi K., Ferrone S., Liao S.-K.;
RT   "Total HLA class I loss in a sarcomatoid renal carcinoma cell line
RT   caused by the coexistence of distinct mutations in the two encoding
RT   beta2-microglobulin genes.";
RL   Cancer Immunol. Immunother. 58:395-408(2009).
//
RX   PubMed=24222125;
RA   Hsieh C.-H., Chen H.-C., Chang Y.-H., Pang S.-T., Kuo M.-L.,
RA   Chuang C.-K., Liao S.-K.;
RT   "Co-existence of epithelioid and fibroblastoid subsets in a
RT   sarcomatoid renal carcinoma cell line revealed by clonal studies.";
RL   Anticancer Res. 33:4875-4889(2013).
//