ID   T79-A3
AC   CVCL_X528
SY   V79-NTRpuro
DR   Wikidata; Q54971619
RX   PubMed=9111301;
RX   PubMed=14997211;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P38489; Escherichia coli nitroreductase nfnB.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_2234 ! V79
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 05-09-14; Last updated: 10-09-24; Version: 13
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RX   PubMed=9111301; DOI=10.1021/jm960794l;
RA   Friedlos F., Denny W.A., Palmer B.D., Springer C.J.;
RT   "Mustard prodrugs for activation by Escherichia coli nitroreductase in
RT   gene-directed enzyme prodrug therapy.";
RL   J. Med. Chem. 40:1270-1275(1997).
//
RX   PubMed=14997211; DOI=10.1038/sj.bjc.6601612; PMCID=PMC2409616;
RA   Helsby N.A., Ferry D.M., Patterson A.V., Pullen S.M., Wilson W.R.;
RT   "2-amino metabolites are key mediators of CB 1954 and SN 23862
RT   bystander effects in nitroreductase GDEPT.";
RL   Br. J. Cancer 90:1084-1092(2004).
//