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Cellosaurus HBEC4-KT (CVCL_X492)

[Text version]
Cell line name HBEC4-KT
Synonyms HBEC4 KT; HBEC 4-KT; HBEC4KT; HBEC4
Accession CVCL_X492
Resource Identification Initiative To cite this cell line use: HBEC4-KT (RRID:CVCL_X492)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Omics: miRNA expression profiling.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Telomerase immortalized cell line
Publications

PubMed=15604268; DOI=10.1158/0008-5472.CAN-04-3703
Ramirez R.D., Sheridan S., Girard L., Sato M., Kim Y., Pollack J., Peyton M., Zou Y., Kurie J.M., DiMaio J.M., Milchgrub S., Smith A.L., Souza R.F., Gilbey L., Zhang X., Gandia K.G., Vaughan M.B., Wright W.E., Gazdar A.F., Shay J.W., Minna J.D.
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
Cancer Res. 64:9027-9034(2004)

PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339
Du L.-Q., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D., Gazdar A.F., Pertsemlidis A.
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010)

PubMed=32586780; DOI=10.1016/j.resinv.2020.04.005
Sato M., Shay J.W., Minna J.D.
Immortalized normal human lung epithelial cell models for studying lung cancer biology.
Respir. Investig. 58:344-354(2020)

Cross-references
Encyclopedic resources Wikidata; Q54881417
Gene expression databases GEO; GSM171896
GEO; GSM253433
GEO; GSM794410
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number19