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Cellosaurus hTERT-EEC-B37 (CVCL_X007)

[Text version]
Cell line name hTERT-EEC-B37
Synonyms hTERT-EEC
Accession CVCL_X007
Resource Identification Initiative To cite this cell line use: hTERT-EEC-B37 (RRID:CVCL_X007)
Comments Problematic cell line: Contaminated. Shown to be a MCF-7 derivative (PubMed=22710073).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00462.
Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=15821114; DOI=10.1677/jme.1.01550
Hombach-Klonisch S., Kehlen A., Fowler P.A., Huppertz B., Jugert F.K., Bischoff G., Schluter E., Buchmann J., Klonisch T.
Regulation of functional steroid receptors and ligand-induced responses in telomerase-immortalized human endometrial epithelial cells.
J. Mol. Endocrinol. 34:517-534(2005)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

DOI=10.1530/jme.1.01550e
Hombach-Klonisch S., Kehlen A., Fowler P.A., Huppertz B., Jugert F.K., Bischoff G., Schluter E., Buchmann J., Klonisch T.
Erratum to: regulation of functional steroid receptors and ligand-induced responses in telomerase-immortalized human endometrial epithelial cells.
J. Mol. Endocrinol. 51:X1-X1(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X007
Biological sample resources BioSample; SAMN03151839
Encyclopedic resources Wikidata; Q54896620
Entry history
Entry creation17-Jul-2014
Last entry update02-May-2024
Version number21