Cellosaurus cell line VOLIN (CVCL

Cellosaurus VOLIN (CVCL_WZ47)

Cross-references
Cell line name	VOLIN
Accession	CVCL_WZ47
Resource Identification Initiative	To cite this cell line use: VOLIN (RRID:CVCL_WZ47)
Comments	Characteristics: Produces IgG lambda. Doubling time: ~5 days (PubMed=27311012). Omics: Transcriptomics; Microarray. Omics: Variations; Array-based CGH. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. Cell type: B-cell; CL=CL_0000236.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu130Val (c.388C>G); ClinVar=VCV000458543; Zygosity=Homozygous (PubMed=27311012).
Disease	Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	82Y
Category	Cancer cell line
Publications	PubMed=23936203; DOI=10.1371/journal.pone.0070430; PMCID=PMC3729839 Muller R., Misund K., Holien T., Bachke S., Gilljam K.M., Vatsveen T.K., Ro T.B., Bellacchio E., Sundan A., Otterlei M. Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells. PLoS ONE 8:e70430.1-e70430.12(2013) PubMed=27311012; DOI=10.1002/gcc.22388 Vatsveen T.K., Borset M., Dikic A., Tian E.-M., Micci F., Lid A.H.B., Meza-Zepeda L.A., Coward E., Waage A., Sundan A., Kuehl W.M., Holien T. VOLIN and KJON -- two novel hyperdiploid myeloma cell lines. Genes Chromosomes Cancer 55:890-901(2016)
Cell line databases/resources	cancercelllines; CVCL_WZ47
Encyclopedic resources	Wikidata; Q98134565
Entry history
Entry creation	06-Sep-2019
Last entry update	10-Apr-2025
Version number	10