Cellosaurus cell line KJON (CVCL

Cellosaurus KJON (CVCL_WZ45)

Cross-references
Cell line name	KJON
Accession	CVCL_WZ45
Resource Identification Initiative	To cite this cell line use: KJON (RRID:CVCL_WZ45)
Comments	Doubling time: ~72 hours (PubMed=27311012). Omics: Transcriptomics; Microarray. Omics: Variations; Array-based CGH. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: B-cell; CL=CL_0000236.
Sequence variations	Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Unspecified (PubMed=27311012). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234Ter (c.702C>A); Zygosity=Hemizygous (PubMed=27311012).
Disease	Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	66Y
Category	Cancer cell line
Publications	PubMed=22806891; DOI=10.1182/blood-2011-08-371567 Holien T., Vatsveen T.K., Hella H., Waage A., Sundan A. Addiction to c-MYC in multiple myeloma. Blood 120:2450-2453(2012) PubMed=23936203; DOI=10.1371/journal.pone.0070430; PMCID=PMC3729839 Muller R., Misund K., Holien T., Bachke S., Gilljam K.M., Vatsveen T.K., Ro T.B., Bellacchio E., Sundan A., Otterlei M. Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells. PLoS ONE 8:e70430.1-e70430.12(2013) PubMed=27311012; DOI=10.1002/gcc.22388 Vatsveen T.K., Borset M., Dikic A., Tian E.-M., Micci F., Lid A.H.B., Meza-Zepeda L.A., Coward E., Waage A., Sundan A., Kuehl W.M., Holien T. VOLIN and KJON -- two novel hyperdiploid myeloma cell lines. Genes Chromosomes Cancer 55:890-901(2016)
Cell line databases/resources	cancercelllines; CVCL_WZ45
Encyclopedic resources	Wikidata; Q94339814
Entry history
Entry creation	06-Sep-2019
Last entry update	10-Apr-2025
Version number	11