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Cellosaurus SKF5 (CVCL_WY49)

[Text version]
Cell line name SKF5
Synonyms SKF-5
Accession CVCL_WY49
Resource Identification Initiative To cite this cell line use: SKF5 (RRID:CVCL_WY49)
Comments Problematic cell line: Misclassified. Parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
Population: Caucasian.
Transfected with: HGNC; 3236; EGFR (with p.Leu682_Ala1210del; HERRet fusion).
Transfected with: HGNC; 9967; RET (with p.Met1_Lys662del; HERRet fusion).
Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
Sequence variations
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
Disease Askin tumor (NCIt: C7542)
Peripheral primitive neuroectodermal tumor (ORDO: Orphanet_370348)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0530 (SK-N-MC)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line

van Weering D.H.J., Medema J.P., van Puijenbroek A.A.F.L., Burgering B.M.T., Baas P.D., Bos J.L.
Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.
Oncogene 11:2207-2214(1995)

PubMed=9121763; DOI=10.1038/sj.onc.1200911
van Puijenbroek A.A.F.L., van Weering D.H.J., van den Brink C.E., Bos J.L., van der Saag P.T., de Laat S.W., den Hertog J.
Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation.
Oncogene 14:1147-1157(1997)

Encyclopedic resources Wikidata; Q98132678
Entry history
Entry creation06-Sep-2019
Last entry update30-Jan-2024
Version number10