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Cellosaurus BON1 RR2 (CVCL_WV98)

[Text version]
Cell line name BON1 RR2
Synonyms RR2
Accession CVCL_WV98
Resource Identification Initiative To cite this cell line use: BON1 RR2 (RRID:CVCL_WV98)
Comments Selected for resistance to: ChEBI; CHEBI:68478; Everolimus (RAD001).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Cys1960Tyr (c.5879G>A); ClinVar=VCV000038003; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic serotonin-producing neuroendocrine tumor (NCIt: C4446)
Serotonin-producing neuroendocrine tumor of pancreas (ORDO: Orphanet_506090)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3985 (BON-1)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

DOI=10.1530/endoabs.49.EP154
Aristizabal Prada E.T., Maurer J., Spottl G., Auernhammer C.J., Nolting S.
Development of an everolimus-resistant BON1 cell line with altered cell cycle and c-Met activity.
Endocr. Abstr. 49:EP154-EP154(2017)

PubMed=29895527; DOI=10.1530/ERC-18-0159; PMCID=PMC7439002
Aristizabal Prada E.T., Spottl G., Maurer J., Lauseker M., Koziolek E.J., Schrader J., Grossman A., Pacak K., Beuschlein F., Auernhammer C.J., Nolting S.
The role of GSK3 and its reversal with GSK3 antagonism in everolimus resistance.
Endocr. Relat. Cancer 25:893-908(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WV98
Encyclopedic resources Wikidata; Q93430383
Entry history
Entry creation06-Sep-2019
Last entry update10-Sep-2024
Version number9