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| Cell line name |
BON1 RR2 |
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| Synonyms |
RR2 |
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| Accession |
CVCL_WV98 |
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| Resource Identification Initiative |
To cite this cell line use: BON1 RR2 (RRID:CVCL_WV98) |
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| Comments |
Selected for resistance to: ChEBI; CHEBI:68478; Everolimus (RAD001).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
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| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Cys1960Tyr (c.5879G>A); ClinVar=VCV000038003; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (from parent cell line).
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| Disease |
Pancreatic serotonin-producing neuroendocrine tumor (NCIt: C4446)
Serotonin-producing neuroendocrine tumor of pancreas (ORDO: Orphanet_506090) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_3985 (BON-1) |
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| Sex of cell |
Male |
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| Age at sampling |
28Y |
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| Category |
Cancer cell line |
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| Publications | DOI=10.1530/endoabs.49.EP154
Aristizabal Prada E.T., Maurer J., Spottl G., Auernhammer C.J., Nolting S.
Development of an everolimus-resistant BON1 cell line with altered cell cycle and c-Met activity.
Endocr. Abstr. 49:EP154-EP154(2017) PubMed=29895527; DOI=10.1530/ERC-18-0159; PMCID=PMC7439002
Aristizabal Prada E.T., Spottl G., Maurer J., Lauseker M., Koziolek E.J., Schrader J., Grossman A., Pacak K., Beuschlein F., Auernhammer C.J., Nolting S.
The role of GSK3 and its reversal with GSK3 antagonism in everolimus resistance.
Endocr. Relat. Cancer 25:893-908(2018) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WV98
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| Encyclopedic resources |
Wikidata; Q93430383
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| Entry history |
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| Entry creation | 06-Sep-2019 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 9 |
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