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Cellosaurus 786-OR (CVCL_WV95)

[Text version]
Cell line name 786-OR
Accession CVCL_WV95
Resource Identification Initiative To cite this cell line use: 786-OR (RRID:CVCL_WV95)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:68478; Everolimus (RAD001).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=31267758; DOI=10.2217/fon-2019-0067
Nogueira I., Dias F., Morais M., Teixeira A.L., Medeiros R.
Everolimus resistance in clear cell renal cell carcinoma: miRNA-101 and HIF-2alpha as molecular triggers?
Future Oncol. 15:2361-2370(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WV95
Encyclopedic resources Wikidata; Q93309883
Entry history
Entry creation06-Sep-2019
Last entry update05-Oct-2023
Version number9