| Cell line name |
U-937/CR |
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| Synonyms |
U937/CR |
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| Accession |
CVCL_WV55 |
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| Resource Identification Initiative |
To cite this cell line use: U-937/CR (RRID:CVCL_WV55) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11986; TOP1; Simple; p.Phe361Ser (c.1082T>C); Zygosity=Unspecified (PubMed=8300570).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0007 (U-937) |
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| Sex of cell |
Male |
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| Age at sampling |
37Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8300570; DOI=10.1016/S0021-9258(17)41964-8
Rubin E.H., Pantazis P., Bharti A., Toppmeyer D., Giovanella B.C., Kufe D.W.
Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin.
J. Biol. Chem. 269:2433-2439(1994) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WV55
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| Encyclopedic resources |
Wikidata; Q98133713
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| Entry history |
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| Entry creation | 05-Jul-2019 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 9 |
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