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Cellosaurus SJG-18 (CVCL_WV12)

[Text version]
Cell line name SJG-18
Synonyms SJG-018
Accession CVCL_WV12
Resource Identification Initiative To cite this cell line use: SJG-18 (RRID:CVCL_WV12)
Comments Omics: Deep exome analysis.
Miscellaneous: STR profile from personal communication of Broad, Simon.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; HGNC:1509; CASP8; Simple; p.Lys148Thr (c.443A>C) (p.Lys207Thr, c.620A>C); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; c.9854-1G>C; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=27693639).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu257Gln (c.770T>A); ClinVar=VCV000012372; Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu258Ter (c.772G>T); ClinVar=VCV000486557; Zygosity=Unspecified (PubMed=27693639).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 79Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10
D3S135815
D5S81812
D7S82010,11
D8S117914,15
D13S31712
D16S53910,11
D18S5114
D21S1131,31.2
FGA21,25
Penta D13
Penta E15,17
TH016,7
TPOX8
vWA15,17

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Publications

CLPUB00518
Goldie S.J.
Studies of FRMD4A in two models of squamous cell carcinoma.
Thesis PhD (2011); University of Cambridge; Cambridge; United Kingdom

PubMed=27693639; DOI=10.1016/j.canlet.2016.09.014; PMCID=PMC5090049
Hayes T.F., Benaich N., Goldie S.J., Sipila K., Ames-Draycott A., Cai W.-J., Yin G.-L., Watt F.M.
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
Cancer Lett. 383:106-114(2016)

CLPUB00517
Pritchard A.J.
Correlating genetic change with changes in cell behaviour in squamous cell carcinoma of the head and neck (SCCHN). Focus on inactivating NOTCH1 mutations.
Thesis PhD (2018); King's College London; London; United Kingdom

Cross-references
Encyclopedic resources Wikidata; Q98132591
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number9