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Cellosaurus SupT1/CCR5/Blam (CVCL_WU94)

[Text version]
Cell line name SupT1/CCR5/Blam
Accession CVCL_WU94
Resource Identification Initiative To cite this cell line use: SupT1/CCR5/Blam (RRID:CVCL_WU94)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P62593; Escherichia coli beta-lactamase bla.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WV22 (SupT1/Blam)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=11884576; DOI=10.1128/JVI.76.7.3522-3533.2002; PMCID=PMC136010
Lineberger J.E., Danzeisen R., Hazuda D.J., Simon A.J., Miller M.D.
Altering expression levels of human immunodeficiency virus type 1 gp120-gp41 affects efficiency but not kinetics of cell-cell fusion.
J. Virol. 76:3522-3533(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WU94
Encyclopedic resources Wikidata; Q98132881
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number12