ID   MOLT-4.CCR5
AC   CVCL_WU92
DR   cancercelllines; CVCL_WU92
DR   Wikidata; Q95990573
RX   PubMed=15169555;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 1606; CCR5.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_F827 ! MOLT-4 clone 8
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 05-10-23; Version: 10
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RX   PubMed=15169555; DOI=10.1186/1742-4690-1-2;
RA   Princen K., Hatse S., Vermeire K., De Clercq E., Schols D.;
RT   "Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line
RT   which is highly sensitive to HIV and suitable for high-throughput
RT   evaluation of CCR5 and CXCR4 antagonists.";
RL   Retrovirology 1:2.1-2.13(2004).
//