ID   TL [Human SiHa contaminated cell line]
SY   Trophoblast-Like
DR   BCRC; 60528
DR   Wikidata; Q98133362
RX   PubMed=3581066;
RX   PubMed=11089925;
RX   PubMed=11409691;
CC   Problematic cell line: Contaminated. Shown to be a Siha derivative (BCRC=60528). Originally thought to originate from the placenta of a 29 year old woman donor.
CC   Population: Japanese.
CC   Doubling time: ~34 hours (PubMed=3581066).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Discontinued: BCRC; 60528; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0032 ! SiHa
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 30-01-24; Version: 6
RX   PubMed=3581066;
RA   Ho C.-K., Chiang H., Li S.-Y., Yuan C.-C., Ng H.-T.;
RT   "Establishment and characterization of a tumorigenic trophoblast-like
RT   cell line from a human placenta.";
RL   Cancer Res. 47:3220-3224(1987).
RX   PubMed=11089925; DOI=10.1078/0171-9335-00091;
RA   Ho C.-K., Chen S.-M., Wang S.-Y.;
RT   "Ouabain resistance of a human trophoblast cell line is not related to
RT   its reactivity to ouabain.";
RL   Eur. J. Cell Biol. 79:765-770(2000).
RX   PubMed=11409691; DOI=10.1007/BF02577537;
RA   Ho C.-K., Au L.-C., Peng H.-J., Wang S.-Y.;
RT   "Transforming growth factor beta may act as an
RT   autocrine-survival-promoting factor for transformed trophoblasts.";
RL   In Vitro Cell. Dev. Biol. Anim. 37:245-250(2001).