Cellosaurus logo
expasy logo

Cellosaurus Tyler2 (CVCL_WS65)

[Text version]
Cell line name Tyler2
Synonyms TYLER2
Accession CVCL_WS65
Resource Identification Initiative To cite this cell line use: Tyler2 (RRID:CVCL_WS65)
Comments Omics: Deep exome analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; VGNC; VGNC:38093; ARID1A; Simple; p.Ala901fs (c.2700_2701insA); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:38297; ATRX; Simple; p.Cys1810Ter (c.5430T>A); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:38514; BRAF; Simple; p.Val588Glu (c.1763T>A); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine transitional cell carcinoma (NCIt: C128126)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Beagle; VBO=VBO_0200131.
Originate from same individual CVCL_WS64 ! Tyler1
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): PubMed=31175136

Markers:
Dog FHC2010239
Dog FHC2054151
Dog FHC2079271,275
Dog PEZ1119
Dog PEZ12263,281
Dog PEZ20176,180
Dog PEZ3134
Dog PEZ5107,111
Dog PEZ6175,183
Dog PEZ8227,236

Run an STR similarity search on this cell line
Publications

DOI=10.1158/1538-7445.AM2012-5258
Sledge D.G., Kiupel M., Madrill N., McNiel E.A.
Characterization of canine lower urinary tract carcinoma cell lines with variable DNA mismatch repair proficiency derived from a single tumor.
Cancer Res. 72 Suppl. 8:5258-5258(2012)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q98133704
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number8