ID   MN7
AC   CVCL_WS46
DR   Wikidata; Q95990414
RX   CelloPub=CLPUB00511;
RX   PubMed=1571849;
RX   PubMed=8079665;
RX   PubMed=9813886;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Osteogenic stromal cell line. Can mineralize in vitro when cultured on a collagen type I matrix.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Secretome proteome analysis by 2D-DE.
CC   Anecdotal: Have been flown in space on Cosmos-2229 (Bion-10) to study growth microgravity (CelloPub=CLPUB00511; PubMed=9813886).
CC   Derived from site: In situ; Bone marrow, stroma; UBERON=UBERON_0007195.
CC   Breed/subspecies: BALB/c.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   12W
CA   Transformed cell line
DT   Created: 05-07-19; Last updated: 29-06-23; Version: 6
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RX   CelloPub=CLPUB00511;
RA   Bierkens J.G.E.A., Maes J., Ooms D., Collier M., Vangenechten C.,
RA   Borremans B., van Vlasselaer P., Schoeters G.;
RT   "Decreased acquisition of osteoblastic phenotype markers and increased
RT   response to interleukin-1 and parathyroid hormone in pre-osteoblast
RT   like cells under microgravity.";
RL   (In) Life sciences research in space. Proceedings of the fifth European symposium held 26 September-1 October 1993 in Arcachon France, ESA SP-366; Oser H., Guyenne T.D. (eds.); pp.25-30; European Space Agency; Noordwijk (1994).
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RX   PubMed=1571849; DOI=10.1007/BF00301635;
RA   Mathieu E., Schoeters G., Vander Plaetse F., Merregaert J.H.;
RT   "Establishment of an osteogenic cell line derived from adult mouse
RT   bone marrow stroma by use of a recombinant retrovirus.";
RL   Calcif. Tissue Int. 50:362-371(1992).
//
RX   PubMed=8079665; DOI=10.1002/jbmr.5650090616;
RA   Mathieu E., Meheus L., Raymackers J., Merregaert J.H.;
RT   "Characterization of the osteogenic stromal cell line MN7:
RT   identification of secreted MN7 proteins using two-dimensional
RT   polyacrylamide gel electrophoresis, western blotting, and
RT   microsequencing.";
RL   J. Bone Miner. Res. 9:903-913(1994).
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RX   PubMed=9813886;
RA   Berezovskaia O.P., Rodionova N.V.;
RT   "The effect of microgravity on osteogenic cells in culture.
RT   Ultrastructural research.";
RL   Tistol. Genet. 32:3-8(1998).
//