ID   LN-2683GS
AC   CVCL_WS30
DR   cancercelllines; CVCL_WS30
DR   GEO; GSM1469041
DR   GEO; GSM2794467
DR   GEO; GSM2794468
DR   GEO; GSM2794469
DR   GEO; GSM2889488
DR   Wikidata; Q95982666
RX   PubMed=21097691;
RX   PubMed=22570425;
RX   PubMed=25622821;
CC   Characteristics: Glioma-derived sphere line. Tumorigenic in nude mice.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Unexplicit; Ex1-9del; Zygosity=Heterozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu224Lys (c.670G>A); ClinVar=VCV000480767; Zygosity=Heterozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro250Leu (c.749C>T); ClinVar=VCV000420136; Zygosity=Heterozygous (PubMed=22570425).
CC   Omics: DNA methylation analysis.
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Brain, right parietal lobe; UBERON=UBERON_0002803.
ST   Source(s): PubMed=22570425
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,10
ST   D16S539: 12
ST   D18S51: 16,19
ST   D21S11: 30,31
ST   D3S1358: 15
ST   D5S818: 10,12
ST   D7S820: 11
ST   D8S1179: 10,14
ST   FGA: 22,23.2
ST   Penta D: 13,14
ST   Penta E: 10
ST   TH01: 7,9.3
ST   TPOX: 8,12
ST   vWA: 14,18
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 19-12-24; Version: 10
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RX   PubMed=21097691; DOI=10.1158/1078-0432.CCR-10-1931;
RA   Sciuscio D., Diserens A.-C., van Dommelen K., Martinet D., Jones G.,
RA   Janzer R.-C., Pollo C., Hamou M.-F., Kaina B., Stupp R., Levivier M.,
RA   Hegi M.E.;
RT   "Extent and patterns of MGMT promoter methylation in glioblastoma- and
RT   respective glioblastoma-derived spheres.";
RL   Clin. Cancer Res. 17:255-266(2011).
//
RX   PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844;
RA   Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K.,
RA   Hamou M.-F., Delorenzi M., Hegi M.E.;
RT   "DNA fingerprinting of glioma cell lines and considerations on
RT   similarity measurements.";
RL   Neuro-oncol. 14:701-711(2012).
//
RX   PubMed=25622821; DOI=10.1186/s13059-015-0583-7; PMCID=PMC4342872;
RA   Kurscheid S., Bady P., Sciuscio D., Samarzija I., Shay T.,
RA   Vassallo I., Van Criekinge W., Daniel R.T., van den Bent M.J.,
RA   Marosi C., Weller M., Mason W.P., Domany E., Stupp R., Delorenzi M.,
RA   Hegi M.E.;
RT   "Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are
RT   associated with expression of a stem cell related HOX-signature in
RT   glioblastoma.";
RL   Genome Biol. 16:16.1-16.15(2015).
//