ID   LN-2669GS
AC   CVCL_WS29
DR   GEO; GSM1469040
DR   GEO; GSM2794464
DR   GEO; GSM2794465
DR   GEO; GSM2794466
DR   GEO; GSM2889490
DR   Wikidata; Q95982664
RX   PubMed=21097691;
RX   PubMed=22570425;
RX   PubMed=25622821;
RX   PubMed=25772239;
RX   PubMed=27717037;
CC   Characteristics: Glioma-derived sphere line. Tumorigenic in nude mice.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323Valfs*19; Zygosity=Homozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=22570425).
CC   Omics: Array-based CGH.
CC   Omics: DNA methylation analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Miscellaneous: STR profile from personal communication of Gusyatiner, Olga.
CC   Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D10S1248: 17
ST   D12S391: 19,21
ST   D13S317: 11,12
ST   D16S539: 10,13
ST   D18S51: 16
ST   D19S433: 15.2,16
ST   D1S1656: 13,15
ST   D21S11: 30,31.2
ST   D22S1045: 16
ST   D2S1338: 16,17
ST   D2S441: 10,15
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 8,9
ST   D8S1179: 11,13
ST   DYS391: 11
ST   DYS570: 18
ST   DYS576: 19
ST   FGA: 24
ST   Penta D: 13
ST   Penta E: 12
ST   SE33: 21.2,27.2
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_S443 ! LN-2669
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 19-12-24; Version: 9
//
RX   PubMed=21097691; DOI=10.1158/1078-0432.CCR-10-1931;
RA   Sciuscio D., Diserens A.-C., van Dommelen K., Martinet D., Jones G.,
RA   Janzer R.-C., Pollo C., Hamou M.-F., Kaina B., Stupp R., Levivier M.,
RA   Hegi M.E.;
RT   "Extent and patterns of MGMT promoter methylation in glioblastoma- and
RT   respective glioblastoma-derived spheres.";
RL   Clin. Cancer Res. 17:255-266(2011).
//
RX   PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844;
RA   Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K.,
RA   Hamou M.-F., Delorenzi M., Hegi M.E.;
RT   "DNA fingerprinting of glioma cell lines and considerations on
RT   similarity measurements.";
RL   Neuro-oncol. 14:701-711(2012).
//
RX   PubMed=25622821; DOI=10.1186/s13059-015-0583-7; PMCID=PMC4342872;
RA   Kurscheid S., Bady P., Sciuscio D., Samarzija I., Shay T.,
RA   Vassallo I., Van Criekinge W., Daniel R.T., van den Bent M.J.,
RA   Marosi C., Weller M., Mason W.P., Domany E., Stupp R., Delorenzi M.,
RA   Hegi M.E.;
RT   "Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are
RT   associated with expression of a stem cell related HOX-signature in
RT   glioblastoma.";
RL   Genome Biol. 16:16.1-16.15(2015).
//
RX   PubMed=25772239; DOI=10.1038/onc.2015.61;
RA   Vassallo I., Zinn P.O., Lai M., Rajakannu P., Hamou M.-F., Hegi M.E.;
RT   "WIF1 re-expression in glioblastoma inhibits migration through
RT   attenuation of non-canonical WNT signaling by downregulating the
RT   lncRNA MALAT1.";
RL   Oncogene 35:12-21(2016).
//
RX   PubMed=27717037; DOI=10.1002/nbm.3610;
RA   Porcari P., Hegi M.E., Lei H.-X., Hamou M.-F., Vassallo I., Capuani S.,
RA   Gruetter R., Mlynarik V.;
RT   "Early detection of human glioma sphere xenografts in mouse brain
RT   using diffusion MRI at 14.1 T.";
RL   NMR Biomed. 29:1577-1589(2016).
//