ID   HL-60/AR
AC   CVCL_WR44
DR   cancercelllines; CVCL_WR44
DR   Wikidata; Q94211566
RX   PubMed=2545346;
RX   PubMed=3860286;
RX   PubMed=9434637;
CC   Group: Space-flown cell line (cellonaut).
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:48120; Anthracycline.
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Anecdotal: Have been flown in space on shuttle flight STS-67 to study the effect of microgravity on multidrug resistance (PubMed=9434637).
CC   Caution: Not to be confused with HL60/AR (Cellosaurus=CVCL_WI27) which is an 5-azacytidine resistant subline of HL-60.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 05-10-23; Version: 10
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RX   PubMed=2545346;
RA   Hindenburg A.A., Gervasoni J.E. Jr., Krishna S., Stewart V.J.,
RA   Rosado M., Lutzky J., Bhalla K.N., Baker M.A., Taub R.N.;
RT   "Intracellular distribution and pharmacokinetics of daunorubicin in
RT   anthracycline-sensitive and -resistant HL-60 cells.";
RL   Cancer Res. 49:4607-4614(1989).
//
RX   PubMed=3860286;
RA   Bhalla K.N., Hindenburg A.A., Taub R.N., Grant S.;
RT   "Isolation and characterization of an anthracycline-resistant human
RT   leukemic cell line.";
RL   Cancer Res. 45:3657-3662(1985).
//
RX   PubMed=9434637; DOI=10.1006/excr.1997.3813;
RA   Piepmeier E.H., Kalns J.E., McIntyre K.M., Lewis M.L.;
RT   "Prolonged weightlessness affects promyelocytic multidrug
RT   resistance.";
RL   Exp. Cell Res. 237:410-418(1997).
//