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Cellosaurus PC3-R-caba (CVCL_WM76)

[Text version]
Cell line name PC3-R-caba
Accession CVCL_WM76
Resource Identification Initiative To cite this cell line use: PC3-R-caba (RRID:CVCL_WM76)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63584; Cabazitaxel.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=27198502; DOI=10.15252/emmm.201506059; PMCID=PMC4931290
Al Nakouzi N., Wang C.K.-D., Beraldi E., Jager W., Ettinger S., Fazli L., Nappi L., Bishop J.L., Zhang F., Chauchereau A., Loriot Y., Gleave M.E.
Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis.
EMBO Mol. Med. 8:761-778(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WM76
Encyclopedic resources Wikidata; Q98128508
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number8